Sale!

Disease Gene Identification: Methods and Protocols (2nd Edition)

Download Disease Gene Identification: Methods and Protocols (2nd Edition) written by Johanna K. DiStefano in PDF format. This book is under the category Genetics and bearing the isbn/isbn13 number 149397470X/9781493974702. You may reffer the table below for additional details of the book.

$19.99

Specifications

book-author

Johanna K. DiStefano

publisher

Humana; 2nd ed. 2018 edition

file-type

PDF

pages

396 pages

language

English

isbn10

149397470X

isbn13

9781493974702


Book Description

This volume; Disease Gene Identification 2nd edition (PDF) presents detailed laboratory procedures in an easy to follow format that can be carried out with success by investigators lacking previous exposure to a specific research method. Chapter guide students through the application of molecular approaches to disease gene identification and case studies and overviews are also presented. Written in the highly successful Methods in Molecular Biology series format; chapters include introductions to their respective topics; lists of the necessary materials and reagents; step-by-step; readily reproducible laboratory protocols; and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical; Disease Gene Identification: Methods and Protocols; 2nd Edition aims to help with the identification and characterization of many more disease-related genes and provide novel; and effective strategies for disease treatment and prevention.

book-author

Johanna K. DiStefano

publisher

Humana; 2nd ed. 2018 edition

file-type

PDF

pages

396 pages

language

English

isbn10

149397470X

isbn13

9781493974702

Table of contents


Table of contents :
Front Matter ….Pages i-x
Front Matter ….Pages 1-1
Identification of Disease Susceptibility Alleles in the Next Generation Sequencing Era (Johanna K. DiStefano, Christopher B. Kingsley)….Pages 3-16
Induced Pluripotent Stem Cells in Disease Modeling and Gene Identification (Satish Kumar, John Blangero, Joanne E. Curran)….Pages 17-38
Development of Targeted Therapies Based on Gene Modification (Taylor M. Benson, Fatjon Leti, Johanna K. DiStefano)….Pages 39-51
What Can We Learn About Human Disease from the Nematode C. elegans? (Javier Apfeld, Scott Alper)….Pages 53-75
Microbiome Sequencing Methods for Studying Human Diseases (Rebecca M. Davidson, L. Elaine Epperson)….Pages 77-90
The Emerging Role of Long Noncoding RNAs in Human Disease (Johanna K. DiStefano)….Pages 91-110
Front Matter ….Pages 111-111
Identification of Disease-Related Genes Using a Genome-Wide Association Study Approach (Tobias Wohland, Dorit Schleinitz)….Pages 113-150
Whole Genome Library Construction for Next Generation Sequencing (Jonathan J. Keats, Lori Cuyugan, Jonathan Adkins, Winnie S. Liang)….Pages 151-161
Whole Exome Library Construction for Next Generation Sequencing (Winnie S. Liang, Kristi Stephenson, Jonathan Adkins, Austin Christofferson, Adrienne Helland, Lori Cuyugan et al.)….Pages 163-174
Optimized Methodology for the Generation of RNA-Sequencing Libraries from Low-Input Starting Material: Enabling Analysis of Specialized Cell Types and Clinical Samples (Kendra Walton, Brian P. O’Connor)….Pages 175-198
Using Fluidigm C1 to Generate Single-Cell Full-Length cDNA Libraries for mRNA Sequencing (Robert Durruthy-Durruthy, Manisha Ray)….Pages 199-221
MiSeq: A Next Generation Sequencing Platform for Genomic Analysis (Rupesh Kanchi Ravi, Kendra Walton, Mahdieh Khosroheidari)….Pages 223-232
Methods for CpG Methylation Array Profiling Via Bisulfite Conversion (Fatjon Leti, Lorida Llaci, Ivana Malenica, Johanna K. DiStefano)….Pages 233-254
Front Matter ….Pages 255-255
miRNA Quantification Method Using Quantitative Polymerase Chain Reaction in Conjunction with Cq Method (Fatjon Leti, Johanna K. DiStefano)….Pages 257-265
Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9 (Jamie L. Everman, Cydney Rios, Max A. Seibold)….Pages 267-292
RNA Interference to Knock Down Gene Expression (Haiyong Han)….Pages 293-302
Using Luciferase Reporter Assays to Identify Functional Variants at Disease-Associated Loci (Anup K. Nair, Leslie J. Baier)….Pages 303-319
Front Matter ….Pages 321-321
Physiologic Interpretation of GWAS Signals for Type 2 Diabetes (Richard M. Watanabe)….Pages 323-351
Identification of Genes for Hereditary Hemochromatosis (Glenn S. Gerhard, Barbara V. Paynton, Johanna K. DiStefano)….Pages 353-365
Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) (Jessica D. Lang, William P. D. Hendricks)….Pages 367-379
The Rise and Fall and Rise of Linkage Analysis as a Technique for Finding and Characterizing Inherited Influences on Disease Expression (Ettie M. Lipner, David A. Greenberg)….Pages 381-397
Back Matter ….Pages 399-400

Reviews

There are no reviews yet.

Be the first to review “Disease Gene Identification: Methods and Protocols (2nd Edition)”

Your email address will not be published. Required fields are marked *

Recent Posts

5 tips for a good business blog

Are you also looking for a good structure for your business blogs? That you finally have a serious and good structure for all your texts that are online? On your website but also on social media. In this review you will find 5 tips from Susanna Florie from her book: How do you…

Study tips from a budding engineer

“Why engineering?” is a question I get often. The answer for me is simple: I like to solve problems. Engineering is a popular field for many reasons. Perhaps this is because almost everything around us is created by engineers in one way or another, and there are always new, emerging and exciting technologies impacting…

How do I study mathematics and pass my exam?

Not sure how best to study math ? Are you perhaps someone who starts studying the day before the exam? Then you know yourself that your situation is not the most ideal. Unfortunately, there is no magic bullet to make you a maths crack or pass your exam in no time . It is important to know that mathematics always builds on…