Hematology and Coagulation: A Comprehensive Review for Board Preparation; Certification and Clinical Practice (2nd Edition)

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Download Hematology and Coagulation: A Comprehensive Review for Board Preparation; Certification and Clinical Practice (2nd Edition) written by Amer Wahed, Andres Quesada, Amitava Dasgupta in PDF format. This book is under the category Medicine and bearing the isbn/isbn13 number 128149647/9780128149645. You may reffer the table below for additional details of the book.

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Specifications

book-author

Amer Wahed, Andres Quesada, Amitava Dasgupta

publisher

Academic Press; 2nd edition

file-type

PDF

pages

324 pages

language

English

asin

B07XPW7RFX

isbn10

128149647

isbn13

9780128149645


Book Description

Hematology and Coagulation: A Comprehensive Review for Board Preparation; Certification and Clinical Practice; 2nd Edition; (PDF) takes an easy-to-read and practical approach to understand hematology and coagulation at a suitable level for both board preparation and refresher courses. The ebook connects the gap between large textbooks and medical technology ebooks written for laboratory technicians; offering a sufficient background in toxicology; genetics; and immunology that residents and medical students need to know in order to become successful physicians. Students will use this quick reference to understand how tests are performed and how to infer results.

This clear and easy-to-read presentation of main topics and comprehensive case studies shows the application of hematopathology on patient care.

Offers a newly updated source that’s in accordance with World Health Organization guidelines on the analysis of hematological malignancies

  • Briefly covers all-important clinical information found in larger textbooks in an easy-to-understand manner
  • Emphasizes essential concepts in hematopathology in such a way that pathology fellows and clinicians can understand methods without being experts in the field

Reviews

It would be of interest to any pathologist or laboratory medicine practitioner in practice wanting a fast review of the subject…a great ebook to review in preparation for the clinical pathology board exam. Score: 86 – 3 Stars” — Doody’s

…In order to be successful; and also to pass the American Board of Pathology examination; all pathology residents must have a good knowledge of hematopathology; including the challenging topics of coagulation and hematology. Hematology and Coagulation 2nd edition meets this challenge head-on…This ebook provides only the most clinically applicable examples designed to educate senior medical students; fellows; and residents  and “refresh” the knowledge base; without overwhelming students; residents; and clinicians.” — Valerie Ng; Ph.D. MD (Alameda County Medical Center/Highland Hospital)

NOTE: The product includes only the ebook; Hematology and Coagulation 2e in PDF. No access codes included.

Additional information

book-author

Amer Wahed, Andres Quesada, Amitava Dasgupta

publisher

Academic Press; 2nd edition

file-type

PDF

pages

324 pages

language

English

asin

B07XPW7RFX

isbn10

128149647

isbn13

9780128149645

Table of contents


Table of contents :
Cover
Hematology and Coagulation
Copyright
Dedication
Preface
1 – Complete blood count and peripheral smear examination
Introduction
Analysis of various parameters by hematology analyzers
Histograms
Red blood cell histogram
Platelet histogram
White blood cell histogram
Red blood cell count and hemoglobin measurement
Hematocrit, RDW, MCV, MCH, and MCHC
Reticulocyte count
White blood cell count and differential
Platelet count, mean platelet volume, platelet differential width
Review of peripheral smear
Red cell variations and inclusions
White blood cell morphology
Platelets
Special situations with complete blood count and peripheral smear examination
Splenic atrophy or postsplenectomy
Microangiopathic hemolysis
Leukoerythroblastic blood picture
Parasites, microorganisms and nonhematopoietic cells in the peripheral blood
Buffy coat preparation
Key points
References
2 – Bone marrow examination and interpretation
Introduction
Fundamentals of bone marrow examination
Dry tap
Granulopoiesis
Erythropoiesis
Monopoiesis, megakaryopoiesis, thrombopoiesis, and other cells in bone marrow
Various bone marrow examination findings and bone marrow failure
Disorders of erythropoiesis, granulopoiesis, and thrombopoiesis
Infections
Granulomatous changes
Storage disorders
Metabolic bone diseases
Metastatic tumors
Hemophagocytic syndrome
Bone marrow necrosis/infarction
Serous atrophy
Bone marrow fibrosis
Reactive lymphoid aggregate
Bone marrow infiltration in lymphoproliferative disorders
Amyloidosis
Key points
References
3 –
Red blood cell disorders
Introduction
Anemia: morphological and etiological classification
Common causes of anemia
Dimorphic red cells
Anemia due to blood loss
Iron deficiency anemia
Lead poisoning
Anemia of chronic disease
Sideroblastic anemia
Megaloblastic anemia
Bone marrow failure
Congenital dyserythropoietic anemia
Hemolytic anemia
Hemolytic anemia due to corpuscular defects
Hemolytic anemia due to membrane defects
Hereditary spherocytosis (aka Minkowski-Chauffard disease)
Hereditary elliptocytosis
Hereditary pyropoikilocytosis
Hereditary stomatocytosis
Rh null disease
Hemolytic anemia due to enzyme defects
Pyruvate kinase deficiency
Glucose-6-phosphate dehydrogenase deficiency
Paroxysmal nocturnal hemoglobinuria
Hemolytic anemias due to extracorpuscular defects
Red cell poikilocytosis
Red cell inclusions
Malaria parasites
Key points
References
4 – Hemoglobinopathies and thalassemias
Introduction
Hemoglobin structure and synthesis
Introduction to hemoglobinopathies and thalassemias
α-thalassemia
Diagnosis of α-thalassemias
β-thalassemia
Diagnosis of β-thalassemia
β-Thalassemia trait
β-Thalassemia major
δ-thalassemia
δβ-Thalassemia
Sickle cell disease
Diagnostic approach to an individual who demonstrates HbS on electrophoresis
Diagnosis of sickle cell trait
Diagnosis of sickle cell trait with concomitant α-thalassemia trait
Diagnosis of sickle cell disease
Diagnosis of sickle cell disease patient who has been transfused or has undergone red blood cell exchange
Diagnosis of sickle cell/β-thalassemia (this in turn can be S/β 0- or S/β+- or S/β++ thalassemia)
Diagnosis of sickle cell disease patient on hydroxyurea
Diagnosis of Hb SC disease
Diagnosis of HbS/hereditary persistence of fetal hemoglobin
Diagnosis of normal individual who has been transfused red blood cells from a sickle cell trait donor
Hereditary persistence of fetal hemoglobin
Other hemoglobin variants
Individuals with high hemoglobin F
Fast, unstable, and other rare hemoglobins
Laboratory investigation of hemoglobinopathies
Gel electrophoresis
High-performance liquid chromatography
Capillary electrophoresis
Reporting normal hemoglobin electrophoresis pattern
Apparent hemoglobinopathy after blood transfusion
Universal newborn screen
Key points
References
5 – Benign white blood cell and platelet disorders
Introduction
Hereditary variation in white blood cell morphology
Changes in white cell counts
Neutrophilia
Eosinophilia and monocytosis
Basophilia
Neutropenia
Lymphocytosis and infectious mononucleosis
Lymphocytopenia
Platelet disorders
Thrombocytopenias
Thrombocytosis
Thrombocytopathia
Key points
References
6 –
Myeloid neoplasms
Introduction
Classification of myeloid neoplasms
Myeloproliferative neoplasm
Chronic myeloid leukemia, BCR-ABL1 positive
Chronic neutrophilic leukemia
Polycythemia vera, primary myelofibrosis, and essential thrombocythemia
Chronic eosinophilic leukemia
Myeloproliferative neoplasm, unclassifiable
Mastocytosis
Myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement
Myelodysplastic/myeloproliferative neoplasms
Myelodysplastic syndromes
Features of dysplasia in red cells, erythroid precursors, granulocytes and megakaryocytes
Arriving at a diagnosis of MDS and subclassifying MDS
Abnormal localization of immature precursors
Cytogenetic abnormalities associated with myelodysplastic syndrome
Unusual situations in myelodysplastic syndrome
Myeloid neoplasms with germline predisposition
Acute leukemia
Blasts
Cytochemistry
Classification of acute myeloid leukemia and diagnosis
Acute myeloid leukemia with recurrent genetic abnormalities
Acute myeloid leukemia, not otherwise specified
Myeloid sarcoma
Myeloid proliferations associated with Down syndrome
Acute myeloid leukemia and flow cytometry
Molecular and acute myeloid leukemia
Cytogenetics and acute myeloid leukemia
Key points
References
7 – Monoclonal gammopathies and their detection
Introduction
Diagnostic approach to monoclonal gammopathy using electrophoresis
Serum protein electrophoresis
Urine electrophoresis
Immunofixation studies
Capillary zone electrophoresis
Free light chain assay
Heavy/light chain assay
Paraprotein interferences in clinical laboratory tests
Plasma cell disorders
Monoclonal gammopathy of undetermined significance
Idiopathic Bence Jones proteinuria
Monoclonal gammopathy of renal significance
POEMS
Plasmacytoma
Monoclonal immunoglobin deposition disease (MIDD)
Plasma cell myeloma
Morphology of plasma cells in myeloma
Immunophenotype of neoplastic plasma cells
Cytogenetics in myeloma diagnosis
Key points
References
8 – Application of flow cytometry in diagnosis of hematological disorders
Introduction
Flow cytometry and mature B-cell lymphoid neoplasms
B-cell markers
Chronic lymphocytic leukemia/small lymphocytic lymphomas
B-cell prolymphocytic leukemia
Mantle cell lymphoma
Follicular lymphoma
Hairy cell leukemia
Burkitt lymphoma
Diffuse large B-cell lymphoma
Flow cytometry and mature T and natural killer–cell lymphoid neoplasm
Detection of clonal or restricted population of T and natural killer cells
Sézary syndrome and mycosis fungoides
T-cell prolymphocytic leukemia
T-cell large granular lymphocytic leukemia
Chronic lymphoproliferative disorder of natural killer cells
Plasma cell dyscrasias
Flow cytometry and acute leukemia
Flow cytometry and subtypes of acute myeloid leukemia
Flow cytometry of B-lymphoblastic leukemia/lymphoma
Flow cytometry of T-lymphoblastic leukemia/lymphoma
Flow cytometry of mixed phenotype acute leukemia
Flow cytometry of blastic plasmacytoid dendritic cell neoplasm
Flow cytometry and myelodysplastic syndrome
Flow cytometry and hematogones
Key points
References
9 – Cytogenetic and genetic abnormalities in hematologic neoplasms
Introduction
Cytogenetic abnormalities in chronic myeloid leukemia
Cytogenetic abnormalities in myelodysplastic syndrome
Cytogenetic abnormalities in patients with myeloid malignancies
Cytogenetic abnormalities in myeloproliferative neoplasms
Cytogenetic abnormalities in acute lymphoblastic leukemia
Cytogenetic abnormalities in multiple myeloma
Cytogenetic and genetic abnormalities in B- and T-cell lymphomas
Key points
References
10 –
Benign lymph node
Introduction
Reactive lymphoid states
Viral lymphadenopathy
Bacterial infections and lymphadenopathy
Cat-scratch lymphadenopathy
Toxoplasma gondii and lymphadenopathy
Granulomatous lymphadenopathy
Necrotizing lymphadenopathy
Progressive transformation of germinal centers
Regressive changes in germinal center
Specific clinical entities with lymphadenopathy
Kikuchi-Fujimoto disease
Kimura disease
Kawasaki disease
Dermatopathic lymphadenitis
Lymphadenopathy in autoimmune diseases
Rosai–Dorfman disease
Langerhans cell histiocytosis
Castleman disease
IgG4-related sclerosing disease–associated lymphadenopathy
Key points
References
11 Precursor lymphoid neoplasms, blastic plasmacytoid dendritic cell neoplasm, and acute leukemias of ambiguous lineage
Introduction
B-lymphoblastic leukemia/lymphoma, NOS
Morphology and immunophenotype
Remission and cure rates
B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
T-lymphoblastic leukemia/lymphoma
Morphology and immunophenotype
Prognosis
NK-lymphoblastic leukemia/lymphoma
Blastic plasmacytoid dendrite cell neoplasm
Acute leukemias of ambiguous lineage
Requirement for assigning lineage to a single blast population
Key points
References
12 – B-cell lymphomas
Introduction
Diffuse large B-cell lymphoma
Morphologic variants include
Molecular subtypes
Immunohistochemistry for suspected diffuse large B-cell lymphoma
Other lymphomas of large B cells
Plasmablastic neoplasms
CD5 positive aggressive B-cell lymphomas
High-grade B-cell lymphomas
B-cell lymphomas unclassifiable
Follicular lymphoma
Usual follicular lymphoma
Patterns of follicular lymphoma
Grading of follicular lymphoma
Immunophenotyping in follicular lymphoma
Genetics of follicular lymphoma
Variants of follicular lymphoma
In situ follicular neoplasia
Duodenal-type follicular lymphoma
Testicular follicular lymphoma
Diffuse variant of follicular lymphoma
Distinct and separate types of follicular lymphoma
Chronic lymphocytic leukemia/small lymphocytic lymphoma
CLL/SLL and certain percentages
Morphology of chronic lymphocytic leukemia in peripheral blood
Immunophenotyping for CLL/SLL
Staging of chronic lymphocytic leukemia
Rai staging
Binet staging
Morphology of lymph nodes in CLL/SLL
CLL/SLL and cytogenetics
CLL/SLL and prognosis
Monoclonal B-cell lymphocytosis
B-cell prolymphocytic leukemia
Mantle cell lymphoma
Prognosis
Indolent mantle cell lymphoma
In situ mantle cell neoplasia
Marginal zone B-cell lymphoma
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
Splenic marginal zone lymphoma
Nodal marginal zone lymphoma
Burkitt lymphoma
Lymphoblastic leukemia/lymphoblastic lymphoma
Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia
Hairy cell leukemia
Approach for diagnosis of lymphoma
Key points
References
13 – T- and natural killer–cell lymphomas
Introduction
Nodal T-cell lymphomas
Angioimmunoblastic T-cell lymphoma
Other nodal T-cell lymphomas of T follicular helper cell origin
Peripheral T-cell lymphoma, not otherwise specified
Anaplastic large cell lymphoma
ALK positive ALCL
ALK-negative ALCL
Extranodal natural killer–/T-cell lymphomas
Breast implant–associated anaplastic large cell lymphoma
Extranodal natural killer–/T-cell lymphoma, nasal type
Intestinal T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
EBV positive T-cell and NK-cell lymphoproliferative diseases of childhood
Cutaneous T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Primary cutaneous CD30 positive T-cell lymphoproliferative disease
Primary cutaneous peripheral T-cell lymphomas, rare subtypes
EBV positive T-cell and NK-cell lymphoproliferative diseases of childhood
Leukemia/disseminated
T-cell prolymphocytic leukemia
T-cell large granular lymphocyte leukemia
Chronic lymphoproliferative disorders of natural killer cells
Aggressive natural killer–cell leukemia
Adult T-cell leukemia/lymphoma
Key points
References
14 –
Hodgkin lymphoma
Introduction
Overview of Hodgkin lymphoma
Classification of Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Sites of involvement
Histology
Immunophenotype
Classic Hodgkin lymphoma
Immunophenotype of CHL
Nodular sclerosis classic Hodgkin lymphoma
Mixed cellularity classic Hodgkin lymphoma
Lymphocyte rich classic Hodgkin lymphoma
Lymphocyte depleted classic Hodgkin lymphoma
Immunostains for diagnosis of Hodgkin lymphoma
Differential diagnosis
Staging of Hodgkin lymphoma
Key points
References
15 – Lymphoproliferative disorders associated with immune deficiencies, histiocytic and dendritic cell neoplasms, and blastic pl …
Introduction
Lymphoproliferative disorders associated with immune deficiency
Lymphoproliferative disorders associated with primary immune deficiency
Lymphoproliferative disorders associated with human immunodeficiency virus infection
Posttransplant lymphoproliferative disorders
Other iatrogenic immunodeficiency–associated lymphoproliferative disorders
Histocytic and dendritic cell neoplasms
Histiocytic sarcoma
Dendritic cell neoplasms
Tumors derived from Langerhans cells
Langerhans cell histiocytosis
Langerhans cell sarcoma
Indeterminate dendritic cell tumor
Interdigitating dendritic cell sarcomas
Follicular dendritic cell sarcoma
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma
Erdheim–Chester disease
Blastic plasmacytoid dendritic cell neoplasm
Key points
References
16 –
Essentials of coagulation
Introduction
Normal hemostasis
Platelets and platelet events
Thrombocytopenia and thrombocytopathia
Hereditary thrombocytopenias
Pseudothrombocytopenia
Thrombocytopathia
Tests for platelet function
Bleeding time
Capillary fragility test
PFA-100
Interpretation of PFA-100
VerifyNow
Plateletworks
Platelet aggregation
Thromboelastography
Use of TEG in management of bleeding patient
Platelet mapping
Idiopathic thrombocytopenic purpura
Heparin-induced thrombocytopenia
Pathophysiology
Assessment of a patient with heparin-induced thrombocytopenia
Calculating the 4T score
Secondary hemostasis
Extrinsic pathway
Intrinsic pathway
Common pathway
Tests for secondary hemostasis
Prothrombin time
Partial thromboplastin time
Thrombin time
PT/PTT mixing study
Factor assays
Tests for bleeding patients
Von Willebrand disease
Diagnosis of various types of von Willebrand disease
Antiplatelets and anticoagulants
Key points
References
17 –
Thrombophilia and their detection
Introduction
Thrombophilia: inherited versus acquired
Factor V Leiden
Activated protein C resistance test
Prothrombin gene mutation
Protien C deficiency
Protein S deficiency
Assays for protein C and protein S
Antithrombin III deficiency
Hyperhomocysteinemia
Increased factor VIII activity
Acquired causes of thrombophilia
Antiphospholipid syndrome
Laboratory testing for lupus anticoagulant
Key points
References
18 –
Sources of errors in hematology and coagulation
Introduction
Errors in common hematology testing
Errors in hemoglobin measurement and red blood cell count
Errors in mean corpuscular volume and related measurements
Errors in WBC counts and WBC differential counts
Errors in platelet count
Errors in specific hematology testing
Cold agglutinins
Cryoglobulins
Pseudothrombocytopenia
Spurious leukocytosis
False-positive osmotic fragility test
Errors in coagulation testing
Errors in PT and aPTT measurements
Errors in thrombin time measurement
Incorrectly filled tubes
Dilution or contamination with anticoagulants
Traumatic phlebotomy
Fibrinolysis products and rheumatoid factor
Platelet aggregation testing with lipemic, hemolyzed, or thrombocytopenic samples
Challenges in anticoagulants and lupus anticoagulant tests
Key points
References
Index
A
B
C
D
E
F
G
H
I
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Z
Back Cover

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