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Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior

Download Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior written by Mikhail Pletnikov, John Waddington in PDF format. This book is under the category Medicine and bearing the isbn/isbn13 number 128009810/9780128009819. You may reffer the table below for additional details of the book.

$19.99

Specifications

book-author

Mikhail Pletnikov, John Waddington

publisher

Academic Press

file-type

PDF

pages

496 pages

language

English

asin

B017XIUB5A

isbn10

128009810

isbn13

9780128009819


Book Description

Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior (PDF) is the first ebook to offer a comprehensive review of the new clinical; theoretical; and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness; typified by schizophrenia; is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors; as well as the interplay among them.

This ebook (Modeling the Psychopathological Dimensions of Schizophrenia) describes the current understanding of the clinical and pathological features of schizophrenia; with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at developmental; molecular; and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia.

This groundbreaking ebook is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions.

  • Edited and authored by leading researchers in the field of schizophrenia and related psychoses
  • Contains a series of reviews of recently available cellular models for the analysis of signaling pathways and gene expression; which complement behavioral neuroscience research in schizophrenia
  • Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia; with an emphasis on the translational potential of these models

NOTE: This sale only contains the ebook Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior in PDF. No access codes come with it.

book-author

Mikhail Pletnikov, John Waddington

publisher

Academic Press

file-type

PDF

pages

496 pages

language

English

asin

B017XIUB5A

isbn10

128009810

isbn13

9780128009819

Table of contents

Front Matter Page iii
Copyright Page iv
Contributors Pages xi-xiii
Preface Page xv
Chapter 1 – Overview of Schizophrenia: Dimensions of Psychopathology Pages 5-15 Arsime Demjaha, Robin M. Murray
Chapter 2 – A Review of the Epidemiology of Schizophrenia Pages 17-30 Alan S. Brown, Florence S. Lau
Chapter 3 – Modeling Dimensions of Psychopathology: Integration with the Epidemiology and Pathobiology of Psychotic Illness Pages 33-38 John L. Waddington
Chapter 4 – Modeling the Positive Symptoms of Schizophrenia Pages 39-54 Tursun Alkam, Toshitaka Nabeshima
Chapter 5 – Animal Models of Psychotic Disorders: Dimensional Approach Modeling Negative Symptoms Pages 55-67 Brian P. Kirby
Chapter 6 – Modeling Cognitive Impairment Pages 69-84 Francesca Managó, Huiping Huang, Papaleo Francesco
Chapter 7 – Modeling Affective Symptoms of Schizophrenia Pages 85-102 Luka Culig, Catherine Belzung
Chapter 8 – Dysregulation of Dopamine Systems in a Developmental Disruption Model of Schizophrenia: Implications for Pathophysiology, Treatment, and Prevention Pages 107-124 Sofia M. Dibble, Yijuan Du, Anthony A. Grace
Chapter 9 – Social Isolation Rearing and Sensorimotor Gating in Rat Models of Relevance to Schizophrenia: What We Know, and What We Do Not Know Pages 125-138 Susan B. Powell, Neal R. Swerdlow
Chapter 10 – Glutamate Pharmacological Models Relevant to Schizophrenia and Psychosis: Can a Receptor Occupancy Normalization Approach Reduce the Gap between Animal and Human Experiments? Pages 139-174 Mark Rafter, Kevin CF. Fone, Paula M. Moran
Chapter 11 – Modeling the Maternal Immune Activation Risk Factor for Schizophrenia Pages 175-191 Natalia Malkova, Wei-Li Wu, Elaine Y. Hsiao
Chapter 12 – Etiological Environmental Models: Virus Infection Models Pages 193-207 Håkan Karlsson
Chapter 13 – Toward a Diathesis-Stress Model of Schizophrenia in a Neurodevelopmental Perspective Pages 209-224 A. Berry, F. Cirulli
Chapter 14 – The Toxoplasma gondii Model of Schizophrenia Pages 225-241 Joanne P. Webster, Poppy H.L. Lamberton, Glenn A. McConkey
Chapter 15 – Maternal Nutritional Deficiencies and Schizophrenia: Lessons from Animal Models with a Focus on Developmental Vitamin D Deficiency Pages 243-264 Darryl W. Eyles, Angela J. Dean
Chapter 16 – Mouse Models of Schizophrenia: Risk Genes Pages 267-284 Lieve Desbonnet
Chapter 17 – Dimensional Deconstruction and Reconstruction of CNV-Associated Neuropsychiatric Disorders Pages 285-302 Noboru Hiroi, Akira Nishi
Chapter 18 – Genetic Rat Models for Schizophrenia Pages 303-324 Bart A. Ellenbroek, Tim Karl
Chapter 19 – Modeling Gene–Gene Interactions in Schizophrenia Pages 327-343 E. Von Cheong, Colm M.P. O’Tuathaigh
Chapter 20 – Modeling Gene–Environment Interaction in Schizophrenia Pages 345-360 Yan Jouroukhin, Ross McFarland, Yavuz Ayhan, Mikhail V. Pletnikov
Chapter 21 – Rodent Models of Multiple Environmental Exposures with Relevance to Schizophrenia Pages 361-371 Urs Meyer
Chapter 22 – Synaptic Abnormalities and Neuroplasticity: Molecular Mechanisms of Cognitive Dysfunction in Genetic Mouse Models of Schizophrenia Pages 375-390 Ruoqi Gao, Theron A. Russell, Peter Penzes
Chapter 23 – hiPSC Models Relevant to Schizophrenia Pages 391-406 Brigham J. Hartley, Yoav Hadas, Kristen J. Brennand
Chapter 24 – Alternative Human Cell Models for Neuropsychiatric Research: Induced Neuronal Cells, Olfactory Epithelium, and Related Resources Pages 407-422 Brian Lo, Daniel Chang, Shin-ichi Kano
Chapter 25 – Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia: Focus on Kynurenic Acid Pages 423-443 Ana Pocivavsek, Francesca M. Notarangelo, Hui-Qiu Wu, John P. Bruno, Robert Schwarcz
Chapter 26 – Dimensions of GSK3 Monoamine-Related Intracellular Signaling in Schizophrenia Pages 447-462 Gohar Fakhfouri, Jivan Khlghatyan, Ilya Sukhanov, Raul R. Gainetdinov, Jean-Martin Beaulieu
Chapter 27 – Hormones and Schizophrenia Pages 463-480 Jayashri Kulkarni, Emmy Gavrilidis, Roisin Worsley
Chapter 28 – Role of Redox Dysregulation in White Matter Anomalies Associated with Schizophrenia Pages 481-500 Aline Monin, Margot Fournier, Philipp S. Baumann, Michel Cuénod, Kim Q. Do
Chapter 29 – Role of Immune and Autoimmune Dysfunction in Schizophrenia Pages 501-516 Emily G. Severance, Robert H. Yolken
Chapter 30 – Future Directions Pages 517-518 Mikhail V. Pletnikov, John L. Waddington
Index Pages 519-531

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