Mathematical Modeling of Pharmacokinetic Data

Download Mathematical Modeling of Pharmacokinetic Data written by David W.A. Bourne in PDF format. This book is under the category Mathematics and bearing the isbn/isbn13 number 1566762049/9781566762045. You may reffer the table below for additional details of the book.


SKU: d1c373ab1570 Category: Tag:



David W.A. Bourne






147 pages









Book Description

This Mathematical Modeling of Pharmacokinetic Data (PDF) is a succinct reference to mathematical modeling and analysis of pharmacokinetic data; this ebook offers important strategies for optimizing the information available from given data. Mathematical Modeling of Pharmacokinetic Data (PDF). It is an excellent resource for researchers, scientists, and students at the higher level.

PLEASE TAKE NOTE That the only thing included in this offer is the PDF version of the ebook “Mathematical Modeling of Pharmacokinetic Data.” There are no access codes provided.

Table of contents

Table of contents :
Content: Cover
Half Title
Title Page
Copyright Page
Table of Contents
Chapter 1: Why Model the Data?
1.1 Condense the Data
1.2 Exploring Mechanisms
1.3 Making Predictions
Chapter 2: General Approach
2.1 General Method
2.2 Error in y Alone
2.3 Parameter Adjustments
Chapter 3: Pharmacokinetic Models
3.1 Compartmental Models
3.2 Physiologically Based Models
3.3 Pharmacodynamic Models
Chapter 4: Simulation of Data
4.1 Explicit Equations
4.2 Implicit Equations
4.3 Differential Equations
4.4 Integration Using Laplace Transforms 4.5 Numerical Integration of Differential EquationsChapter 5: Initial Estimates
5.1 Graphical Methods
5.2 Linear Regression
5.3 Curve Stripping
5.4 Area under the Curve Estimation
5.5 Deconvolution
Chapter 6: Nonlinear Regression
6.1 Grid Search Method
6.2 Steepest Descent Method
6.3 Gauss-Newton Methods
6.4 Simplex Method
6.5 Local Minima
Chapter 7: Weighting Schemes
7.1 Equal Weight
7.2 Variance Model
7.3 Iteratively Reweighted Least Squares
7.4 Extended Least Squares
7.5 Bayesian Methods
7.6 Analysis of Population Data
Chapter 8: Evaluation of Program Output 8.1 Tabular Output8.2 Graphical Output
8.3 Statistical Output
Chapter 9: Experimental Design
9.1 Pilot Study
9.2 Identifiability-Sampling Sites
9.3 Optimal Sampling-Sampling Times
9.4 Model Testing

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