Giuseppe Gasparre, Anna Maria Porcelli
The Human Mitochondrial Genome: From Basic Biology to Disease is a comprehensive and up-to-date assessment of human mitochondrial genomics, integrating basic research to translational medicine across a variety of disease types. It is available as a PDF document. In this article, scientists from all over the world explain the fundamental aspects of the biology of human mitochondrial DNA (mtDNA), such as its maintenance and repair, as well as its inheritance and segregation. In addition, topics such as the development and utilization of mtDNA, mutations, models, and methodologies for research on the functional aspects of mtDNA are discussed. Cancer, age-related diseases, mtDNA depletion, neurodegenerative diseases, deletion diseases, and point mutation diseases are some of the disease categories that are covered in the topic of disease, which is reinforced with attempts for therapeutic options. Among the treatment strategies that have been investigated in depth are nucleosides supplementation, mitoZNF nucleases, and mitoTALENs nucleases.
As funding for research on mtDNA continues to increase, a growing number of doctors, scientists, and clinicians are focusing their attention on the relationship of mtDNA with disease. This ebook gives the tools and background information essential to do novel and effective research in this exciting space. Whether your goal is to distinguish a disease-related mutation or a haplogroup-defining variant, or to discover developing treatment pathways, this ebook has you covered.
- Describes and analyzes important research processes and points of view that younger scientists should learn.
- Includes a team of authors from all around the world who are considered to be experts in their fields, ranging from basic biologists to clinician-scientists.
- Discussion of the disease, along with diagnostic and treatment approaches that are now being used in clinical practice
- Comprehensive analysis of recent scientific discoveries and technology improvements made in the field; paves the way for future mtDNA investigations; identifies variants and mutations; conducts pathogenic analysis; and details therapeutic options.
PLEASE TAKE NOTE That the only thing that is included in the purchase is the PDF version of the book “The Human Mitochondrial Genome: From Basic Biology to Disease.” There are no access codes contained within.