Stroke: Pathophysiology; Diagnosis; and Management (6th Edition)

Download Stroke: Pathophysiology; Diagnosis; and Management (6th Edition) written by James C. Grotta, David Mendelow, Eng H. Lo, Ralph L. Sacco, Lawrence KS Wong, Gregory W Albers, Joseph P. Broderick in PDF format. This book is under the category Medicine and bearing the isbn/isbn13 number 323295444/9780323295444. You may reffer the table below for additional details of the book.


SKU: e250c59336b5 Category: Tag:



James C. Grotta, David Mendelow, Eng H. Lo, Ralph L. Sacco, Lawrence KS Wong, Gregory W Albers, Joseph P. Broderick


Elsevier; 6th edition




1504 pages









Book Description

This updated version of Stroke: Pathophysiology, Diagnosis, and Management, which is now available in its 6th edition (PDF), provides easy access to the most recent results from research as well as management strategies for cerebrovascular disease. Following on from where J. P. Mohr and his colleagues left off, a new team of editors — Drs. Grotta, Broderick, Albers, Lo, Mendelow, Kasner, Sacco, and Wong — head the 6th edition of this famous textbook, which is produced by the most eminent stroke experts from around the world.


  • Contains the extracted evidence and underlined degree of proof.
  • You will be equipped with the most recent findings if you make use of data from recently completed endovascular studies.
  • You are able to make rapid and precise diagnosis because to the abundance of full-color CT scans and pathology slides.
  • Provides information regarding recent developments in diagnostic procedures, such as ultrasound, computed tomography (including CT perfusion and CT angiography), magnetic resonance imaging (including MR perfusion techniques), and angiography.
  • This article highlights recent discoveries in the areas of genetic risk factors, primary prevention of stroke, infectious diseases and stroke, recovery therapies such as brain stimulation, robotics, and telerehabilitation, and trial design.
  • You will be able to recognize the clinical signs of stroke, use the most recent laboratory and imaging testing to arrive at a diagnosis, and devise an effective medication and surgical treatment plan with the help of comprehensive and professional clinical advice.
  • Includes exhaustive treatment of recent developments in the molecular biology of cell death; risk factors and prevention; recent developments in diagnostics and stroke imaging; and therapeutic alternatives, including a full assessment of thrombolytic drugs and emerging data for endovascular therapy.
  • Intracellular Signaling: Mediators and Protective Responses, The Neurovascular Unit and Responses to Ischemia, Mechanisms of Cerebral Hemorrhage, Stroke Related to Surgery and Other Procedures, Cryptogenic Stroke, and Interventions to Improve Recovery after Stroke are some of the brand-new chapters included in this updated edition.


PLEASE TAKE NOTICE That the only thing that is being offered for sale is the PDF version of Stroke: Pathophysiology, Diagnosis, and Management, 6th Edition. There are no online codes provided.

Table of contents

Front Matter,Copyright,Foreword to the Sixth Edition,Preface,List of Contributors,AHA Evidence-based ClassificationsEntitled to full textSection I: PathophysiologyIntroduction, Page 1
1 – Vascular Biology and Atherosclerosis of Cerebral Vessels, Pages 3-12
2 – Mechanisms of Thrombosis and Thrombolysis, Pages 13-27
3 – Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease, Pages 28-46.e7
4 – Histopathology of Brain Tissue Response to Stroke and Injury, Pages 47-59
5 – Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death, Pages 60-79.e5
6 – Intracellular Signaling: Mediators and Protective Responses, Pages 80-89
7 – The Neurovascular Unit and Responses to Ischemia, Pages 90-101
8 – Mechanisms of Cerebral Hemorrhage, Pages 102-112.e6
9 – White Matter Pathophysiology, Pages 113-128
10 – Inflammation and Immune Response, Pages 129-140.e5
11 – Mechanisms of Plasticity, Remodeling and Recovery, Pages 141-148
12 – Genetics and Vascular Biology of Angiogenesis and Vascular Malformations, Pages 149-162.e7
Introduction, Page 163
13 – Global Burden of Stroke, Pages 165-206
14 – Stroke Disparities, Pages 207-216
15 – Modifiable Risk Factors and Determinants of Stroke, Pages 217-233
16 – Prognosis after Stroke, Pages 234-252.e10
17 – Vascular Dementia and Cognitive Impairment, Pages 253-267.e7
18 – Genetic Basis of Stroke Occurrence, Prevention and Outcome, Pages 268-279
19 – Preventing a First Stroke, Pages 280-291
Introduction, Page 293
20 – Classification of Ischemic Stroke, Pages 295-307.e4
21 – Clinical Scales to Assess Patients with Stroke, Pages 308-325.e6
22 – Carotid Artery Disease, Pages 326-346.e7
23 – Anterior Cerebral Artery Disease, Pages 347-361.e8
24 – Middle Cerebral Artery Disease, Pages 362-392.e10
25 – Posterior Cerebral Artery Disease, Pages 393-412.e5
26 – Vertebrobasilar Disease, Pages 413-448.e7
27 – Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-vessel Disease, Pages 449-465.e4
28 – Intracerebral Hemorrhage, Pages 466-515.e12
29 – Aneurysmal Subarachnoid Hemorrhage, Pages 516-536
30 – Arteriovenous Malformations and Other Vascular Anomalies, Pages 537-549
31 – Stroke and Other Vascular Syndromes of the Spinal Cord, Pages 550-560
Introduction, Page 561
32 – Cardiac Diseases, Pages 563-575.e5
33 – Atherosclerotic Disease of the Proximal Aorta, Pages 576-590
34 – Stroke Related to Surgery and Other Procedures, Pages 591-598
35 – Arterial Dissections and Fibromuscular Dysplasia, Pages 599-618.e7
36 – Collagen Vascular and Infectious Diseases, Pages 619-631.e6
37 – Reversible Cerebral Vasoconstriction Syndromes, Pages 632-639
38 – Hypertensive Encephalopathy, Pages 640-647
39 – Stroke and Substance Abuse, Pages 648-657.e14
40 – Moyamoya Disease, Pages 658-673
41 – CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Pages 674-679
42 – Hematologic Disorders and Stroke, Pages 680-694.e5
43 – Migraine and Stroke, Pages 695-706
44 – Cryptogenic Stroke, Pages 707-715
45 – Cerebral Venous Thrombosis, Pages 716-729
Introduction, Page 731
46 – Ultrasonography, Pages 733-750.e8
47 – Computed Tomography-based Evaluation of Cerebrovascular Disease, Pages 751-767
48 – Magnetic Resonance Imaging of Cerebrovascular Diseases, Pages 768-789.e9
49 – Cerebral Angiography, Pages 790-805
Introduction, Page 807
50 – Prehospital and Emergency Department Care of the Patient with Acute Stroke, Pages 809-825
51 – Intravenous Thrombolysis, Pages 826-848
52 – Antithrombotic Therapy for Treatment of Acute Ischemic Stroke, Pages 849-867.e5
53 – General Stroke Management and Stroke Units, Pages 868-884
54 – Critical Care of the Patient with Acute Stroke, Pages 885-915.e9
55 – Pharmacologic Modification of Acute Cerebral Ischemia, Pages 916-936.e5
56 – Treatment of “Other” Stroke Etiologies, Pages 937-952.e9
57 – Medical Therapy of Intracerebral and Intraventricular Hemorrhage, Pages 953-962
58 – Rehabilitation and Recovery of the Patient with Stroke, Pages 963-971
59 – Interventions to Improve Recovery after Stroke, Pages 972-980.e5
60 – Enhancing Stroke Recovery with Cellular Therapies, Pages 981-991
61 – Antiplatelet Therapy for Secondary Prevention of Stroke, Pages 992-1013
62 – Secondary Prevention of Cardioembolic Stroke, Pages 1014-1029.e4
63 – Conduct of Stroke-Related Clinical Trials, Pages 1030-1041
Introduction, Pages 1043-1046
64 – Endovascular Therapy of Extracranial and Intracranial Occlusive Disease, Pages 1047-1057
65 – Endovascular Treatment of Acute Ischemic Stroke, Pages 1058-1070
66 – Endovascular Treatment of Cerebral Aneurysms, Pages 1071-1088.e6
67 – Interventional Therapy of Brain and Spinal Arteriovenous Malformations, Pages 1089-1103
68 – Dural Arteriovenous Malformations, Pages 1104-1116
Introduction, Pages 1117-1118
69 – Surgery of Anterior and Posterior Aneurysms, Pages 1119-1136
70 – Surgery for Intracerebral Hemorrhage, Pages 1137-1147
71 – Intraventricular Hemorrhage, Pages 1148-1157
72 – Surgical Management of Cranial and Spinal Arteriovenous Malformations, Pages 1158-1170
73 – Surgical Cavernous Malformations and Venous Anomalies, Pages 1171-1180
74 – Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis, Pages 1181-1191
75 – Extracranial to Intracranial Bypass for Cerebral Ischemia, Pages 1192-1199
76 – Decompressive Craniectomy for Infarction and Hemorrhage, Pages 1200-1217
Index, Pages 1219-1254

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